Compound Sulfachlorpyridazine Souium Powder

Shengdaan® Compound Sulfachloropyridazine Sodium Powder is a broad-spectrum antibiotic. It has a strong killing effect on Gram-positive bacteria, negative bacteria, toxoplasma, eperythrocytes, Leptospira, etc., and has a strong effect on other antibiotics. The effect of infection prevention and treatment caused by drug-resistant pathogenic bacteria is still significant, and it can effectively control livestock hyperthermia, systemic infection, local infection, genitourinary system disease, digestive tract disease, and secondary infections and complications caused by various reasons. At the same time, it also has the effect of killing coccidia and protozoa, and can quickly solve the main cause of enterotoxic syndrome. The main ingredient is sulfachlordazine sodium (SCP). The innovatively used excipients can protect the intestinal mucosa in all directions, can well alleviate the harm caused by clostridia toxins, alleviate gastrointestinal symptoms, and have a good effect on the current overuse of antibiotics or other unexplained diarrhea.

Shengdaan® mainly controls the following livestock and poultry diseases:

□ Postpartum infections of sows (endometritis, vaginitis, mastitis), yellow and white scour of piglets, paratyphoid fever, arthritis, encephalitis, abscesses, etc.

□ Porcine reproductive and respiratory disorder syndrome, post-weaning multi-system failure syndrome of piglets and secondary infections caused by viral diseases.

□ Toxoplasma, eperythrocytes, Leptospira, Bordetella septicum, Staphylococcus and their mixed infections.

Each 100 grams of finished product contains 62.5 grams of sulfachlordazine sodium and 12.5 grams of trimethoprim.

• Low toxicity and high efficiency, no kidney crystallization, high safety;
  

• Broad-spectrum sterilization, high-efficiency antiprotozoal, and prevention of various bacterial infections;

• TMP synergistic effect, the two active ingredients are absorbed simultaneously, and the curative effect is increased by 6-8 times;

After oral administration of TMP, the time to reach the peak blood drug is 4h and the half-life is 3.9h. The time to reach the peak blood drug after oral administration of sulfachlordazine sodium is 4.4h and the half-life is 3.7h. The two active ingredients are planned to reach the peak blood drug at the same time. Excretion ensures the synergistic antibacterial effect. The half-life of sulfadimethoxine is 7h, and the half-life of sulfadimethoxine is about 24h, which greatly affects their synergistic effect with TMP.

Figure, the drug-time curve of TMP and sulfa drugs

Li Shaowen (2009) of the School of Veterinary Medicine of Huazhong Agricultural University determined the minimum inhibitory concentration of four sulfonamides. The test used isolated pathogenic strains from various farms. Sulfonamides were added with TMP at a ratio of 5:1. The results show that the four sulfa drugs have good inhibitory effects on Streptococcus suis, Pasteurella suis, etc., especially the combination of sulfachlordazine sodium has a slightly better inhibitory effect on Pasteurella suis and Pasteurella avian. The other three sulfa drugs. Salmonella has a certain resistance to the four sulfa drugs, and the treatment of Salmonella requires compatible drugs.

Table. Minimum inhibitory concentration of four sulfa drugs on pathogenic bacteria isolates

    SM2: Sulfadimethoxine sodium; SMD: Sulfadimethoxine sodium; SMM: Sulfadimethoxine sodium; SCP: Sulfachlorazine sodium

Advantage 2, high efficiency, low toxicity, high safety

As the main metabolite of sulfa drugs in the body-acetylated sulfonamide has poor solubility, it is easy to form crystals in the renal tubules and renal pelvis when excreted through the kidneys, causing nephrotoxicity. The acetylation rate of different sulfa drugs is different, and its nephrotoxicity Different sizes. Among them, the acetylation rate of sulfachlordazine sodium, the active ingredient of Shengdaan®, is only 5% (the acetylation rate of sulfamethazine sodium is 21%, and the acetylation rate of sulfamethoxine sodium is 10%), so Sulfachlordazine sodium has the lowest toxicity among the three sulfa drugs. The test results showed that the sulfachlordazine sodium was fed continuously for 13 weeks at seven times the dose, and no adverse effects were seen in the experimental pig herd. In continuous use of therapeutic doses, Shengdaan will not produce crystaluria. The highest blood drug concentration can be reached within 1-2 hours after administration. The drug is distributed in the tissues and organs of the whole body and is excreted after 6-8 hours without accumulation and no damage to the kidneys.

Advantage 3, minimal residue, short drug withdrawal period

Among the three commonly used sulfa drugs, the half-life of sulfachlordazine sodium is the shortest, only 3.7h, so it is eliminated quickly in the animal body, and the withdrawal period is only 4 days in pigs. The sulfamethazine sodium and sulfamethoxine sodium have a long half-life and high drug residue, and their legal drug withdrawal period on pigs is both 28 days.

Advantage 4. A new generation of sulfa drugs, a combination of "Three Musketeers"

The antibacterial spectrum of Shengdaan is similar to that of sulfamonomethoxine, which can effectively control the infections of Toxoplasma, atrophic rhinitis, sow triad, Pasteurella, Streptococcus, Escherichia coli, Salmonella, Actinobacillus pleuropilis, etc. Or disease, can replace the use of sulfamethazine sodium and sulfamethoxine sodium. As a slow bacteriostatic agent, the combination of Shengdaan and the fast bacteriostatic agent doxycycline has an additive effect, which can more effectively control bacterial infections in pig farms. In clinical practice, "Shengdaan+Doxycycline" is often used. The "Three Musketeers" combination of "cyclin + tiamulin" can also control respiratory diseases such as mycoplasma infection at the same time.