Shengligao ® is a compound broad-spectrum antimicrobial drug. Guanomycin inhibited bacterial protein synthesis by acting on the 30S subunit of bacteria, mainly targeting Gram-negative bacteria. Lincomycin inhibits protein synthesis by acting on the 50S subunit of bacteria, targeting Gram-positive bacteria, and the combination of the two has synergistic effect, killing a variety of pathogens.
【Name of Veterinary drug】
General name: Daguanmycin hydrochloride lincomycin hydrochloride soluble powder
Product Name: Shengligao
【Main ingredients】 Daguanmycin hydrochloride, lincomycin hydrochloride
【Appearance】 This product is white or white like powder.
【Pharmacological effect】 Pharmacodynamic macromycin is an aminoglycoside antibiotic, which has moderate inhibitory effect on a variety of Gram-negative bacilli, such as Escherichia coli, Salmonella, Shigella, Proteus, etc. It is sensitive to Streptococcus, pneumococcus, Staphylococcus epidermidis and certain mycoplasmas (e.g., Mycoplasma gallinum, Mycoplasma Turkey, Mycoplasma synovial, etc.). It is not sensitive to Streptococcus aureus and Staphylococcus aureus. Often resistant to Pseudomonas aeruginosa and Treponema SPP. Intestinal bacteria are widely resistant to macromycin, but do not show cross resistance to streptomycin. Lincomycin has good antibacterial activity against anaerobic bacteria, such as Fusobacterium, digestive coccus, digestive streptococcus, Clostridium tetani, Clostridium perfringens and most actinomycetes, etc. Lincomycin mainly acts on the 50S subunit of bacterial ribosomes and affects protein synthesis by inhibiting the elongation of peptide chains.
Pharmacokinetic macromycin only absorbed 7% after oral administration, but maintained a high concentration in the gastrointestinal tract. The tissue concentration of the drug is lower than the serum concentration. It is not easy to enter the cerebrospinal fluid or eye, and the binding rate of plasma protein is not high. Drugs are mostly excreted by glomerular filtration in their original form. Lincomycin was poorly absorbed by oral administration, and its bioavailability was 30%-40%. Mixed feeding can reduce the absorption rate and amount. Chickens were given 50mg of this product (dissolved in drinking water) per kg body weight for 7 days. During the experiment, lincomycin in plasma reached 0.14μg/ml, while the concentration of macromycin was very small, and only exceeded 0.1μg/ml after 7 days of the experiment.
【Drug interaction】 (1) When combined with lincomycin, the antimicrobial activity against Mycoplasma was significantly increased and the antimicrobial spectrum was expanded.
(2) The combination of lincomycin and anticholinesterase can reduce the efficacy of the latter.
(3) Combined with erythromycin has antagonistic effect.
【 Function and use 】 Antibiotic drugs. For infection of Gram-negative bacteria, Gram-positive bacteria and mycoplasma.
【Usage and dosage】 based on this product. Mixed drink: 0.5 ~ 0.8g of water per 1L for 3 ~ 5 days of age.
【Adverse reactions】 According to the prescribed usage and dosage, no adverse reactions have been observed.
【Note】 Only for 5 to 7 days old chicks.
【Rest period】 no customization.
【Specification】 100g: 40g (40 million units) and 20g lincomycin (according to C18H34N2O6S calculation)
Store sealed and kept in a dry place.
Address: No. 118, Tongji Road, high tech Zone, Jining City, Shandong Province
+86 15554479245
shenglibio@gmail.com
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